High levels of testosterone course through the bulging veins of Triple 9. At the heart of this man’s world is venomous moll Irina Vlaslov (Kate Winslet), who takes charge of the Russian-Israeli mob while her husband Vassili (Igor Komar) languishes behind bars. She puts the squeeze on private security contractor Michael Belmont (Chiwetel Ejiofor) and his team of dirty cops and Special Ops veterans. Irina insists that Michael and his accomplices pull off the heist of valuable computer files from a safe house. It’s an impossible task, so Michael, homicide detective Jorge Rodriguez (Clifton Collins Jr), street cop Marcus Atwood (Anthony Mackie) and brothers Russell and Gabe Welch (Aaron Paul, Norman Reedus) decide to buy themselves extra time with a distraction.
Former Special Forces operative Wade Wilson (Ryan Reynolds) is a low-rent assassin for hire, who works out of a bar called Sister Margaret’s Home For Wayward Girls run by his wise-cracking buddy Weasel (TJ Miller). A loner by heart, Wade falls in love with sassy sex club worker Vanessa (Morena Baccarin), who shares his passion for creative love-making. The furious bed-hopping ends when Wade discovers he has inoperable cancer. A recruiter (Jed Rees) from an experimental program known as WeaponX invites Wade to undergo a radical procedure, which aggressively attacks the cancerous cells. Sadistic program director Ajax (Ed Skrein) and henchwoman Angel Dust (Gina Carano) torture and abuse Wade, transforming him into a hideously deformed mutant with the power of self-healing. Reborn as Deadpool, Wade moves in with a no-nonsense landlady named Al (Leslie Uggams). Aided by two bona fide X-Men – Colossus (voiced by Stefan Kapicic) and Negasonic Teenage Warhead (Brianna Hildebrand) – Wade vows revenge on Ajax and his underlings. Relentlessly lurid and unapologetically foul-mouthed, Deadpool is a sinful treat.